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GA does not influence the activities of caspase-3, −8 or −9 in the NCI-H1993 xenograft model. NCI-H1993 xenografts were treated with the indicated dose of GA, vehicle or positive control for 2 h on day 21 of the efficacy study, prior to caspase colorimetric protease kit analysis. Values are expressed as the mean ± standard deviation, n=10. GA, gambogic acid; i.p., intraperitoneal; i.v., intravenous; OD, optical density.
