Figure 4. Thrombus development is not altered by common antiplatelet agents.

(A) WT and Gpvi^–/– mice were infected i.p. as above for 7 days. Thrombi were examined by H&E and (B) quantified by point counting of large vessels per tissue section. (C) WT mice were treated with clopidogrel (50 mg/kg i.v.) on day 3 after infection and daily (15 mg/kg i.v.) thereafter; thrombi were examined at day 7. (D) WT mice were treated with aspirin (30 mg/l in drinking water) on day 5 after infection and daily thereafter; thrombi were examined after 13 days and (E) were quantified by point counting as above. (F) WT mice were treated daily with heparin sodium (100 U/kg i.v.) from day 3 after infection; thrombi were examined at day 7 after infection. (G) WT and Rag1^–/– mice were infected i.p as above; thrombi were examined after 7 days and (H) were quantified as above. All H&E was performed on frozen liver sections; all images are representative. Scale bars: 100 μm. Graphs show mean + SD. Experiments were performed at least twice with each group containing ≥ 4 mice.