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. 2015 Nov 3;125(12):4572–4586. doi: 10.1172/JCI82045

Figure 2. Immune cells and specialized ECM organization in adult small intestinal villi.

Figure 2

Confocal microscope images of adult mouse small intestinal villi after whole-mount immunostaining. (A) DCs (CD11c, red) are closely associated with SMC fibers (αSMA, cyan). Inset: ×5 3D Surpass projection of DCs (CD11c, red) interacting with SMC fibers (arrowheads). DCs associated with SMC fibers can be observed sampling the intestinal lumen (arrow). Macrophages are shown in green (F4/80). (B) Fibronectin (green) is highly expressed on villus SMCs (αSMA, red). (C) Expression of periostin (red) and tenascin C (green) is restricted to the crypts (*) and villi, respectively. Scale bars: 50 μm, A–C.