Table II.
Univariate and multivariate Cox proportional hazards analyses for prognostic factors in patients with non-small cell lung cancer.
| Overall survival | |||
|---|---|---|---|
| Variable | HR | 95% CI | P-value |
| Univariate analysis | |||
| Gender (female vs. male) | 0.8090 | 0.4026–1.6260 | 0.5508 |
| Age (≥60 vs. <60 years) | 0.7849 | 0.4453–1.3830 | 0.4011 |
| Tumor histology (adenocarcinomas vs. quamous cell carcinoma) | 1.0610 | 0.6021–1.8690 | 0.8383 |
| T status (T3+T4 vs. T1+T2) | 1.7960 | 0.9609–3.3570 | 0.0627 |
| Lymph node status (N+ vs. N0) | 3.5700 | 1.8140–7.0260 | <0.0001a |
| TNM stage (III+IV vs. I+II) | 6.4060 | 3.5500–11.560 | <0.0001a |
| Grading (G3 vs. G1+G2) | 1.9020 | 1.0480–3.4490 | 0.0315a |
| Smoking history (yes vs. no) | 1.3560 | 0.7435–2.4730 | 0.3187 |
| Ventilatory function (abnormal vs. normal) | 1.2590 | 0.7149–2.2190 | 0.4237 |
| Small airway function (abnormal vs. normal) | 1.7240 | 0.8064–3.6840 | 0.1550 |
| Anatomical classification (central vs. peripheral) | 1.5630 | 0.8829–2.7680 | 0.1222 |
| Notch 1 expression (high vs. low) | 2.0800 | 1.1370–3.8040 | 0.0151a |
| Notch 3 expression (high vs. low) | 3.7220 | 1.9590–7.0720 | <0.0001a |
| JAG1 expression (high vs. low) | 1.9760 | 1.1180–3.4940 | 0.0170a |
| DLL4 expression (high vs. low) | 1.9620 | 1.0370–3.7130 | 0.0348a |
| Multivariate analysis | |||
| Gender (female vs. male) | 0.8756 | 0.3004–2.5523 | 0.8076 |
| Age (≥60 vs. <60 years) | 1.0026 | 0.5048–1.9913 | 0.9940 |
| Tumor histology (adenocarcinomas vs. quamous cell carcinoma) | 1.0097 | 0.5309–1.9202 | 0.9766 |
| T status (T3+T4 vs. T1+T2) | 0.8430 | 0.3717–1.9121 | 0.6827 |
| Lymph node status (N+ vs. N0) | 1.7543 | 0.7431–4.1411 | 0.1997 |
| TNM stage (III+IV vs. I+II) | 5.1447 | 2.1070–12.5621 | 0.0003a |
| Grading (G3 vs. G1+G2) | 1.5180 | 0.7615–3.0263 | 0.2357 |
| Smoking history (yes vs. no) | 0.8977 | 0.3527–2.2850 | 0.8209 |
| Ventilatory function (abnormal vs. normal) | 1.4652 | 0.6636–3.2350 | 0.3445 |
| Small airway function (abnormal vs. normal) | 1.7839 | 0.6867–4.6345 | 0.2347 |
| Anatomical classification (central vs. peripheral) | 1.8915 | 0.9343–3.8291 | 0.0765 |
| Notch 1 expression (high vs. low) | 0.9105 | 0.3855–2.1510 | 0.8308 |
| Notch 3 expression (high vs. low) | 2.5126 | 1.1383–5.5460 | 0.0226a |
| JAG1 expression (high vs. low) | 1.1646 | 0.4850–2.7970 | 0.7331 |
| DLL4 expression (high vs. low) | 1.2515 | 0.5477–2.8600 | 0.5947 |
a
P<0.05. JAG1, Jagged 1; DLL, Delta-like 4; CI, confidence interval; HR, hazard ratio; TNM, tumor-node-metastasis.