Table 4.
The risk of micro- and macroalbuminuria associated with a 0.1 μg/l increase in serum OPG
| Model | Adjustment | Microalbuminuria (n = 103) | p valuea | Micro- and macroalbuminuria (n = 117) | p valueb |
|---|---|---|---|---|---|
| Model 1 | Unadjusted | 1.042 (1.026–1.058) | <0.0001 | 1.039 (1.022–1.056) | <0.0001 |
| Model 2 | Adjusted for sex, current smoking, current alcohol intake, ACEI/ARB use and family history of diabetes | 1.032 (1.017–1.046) | <0.0001 | 1.034 (1.019–1.050) | <0.0001 |
| Model 3 | Further adjusted for BMI and WHR, based on Model 2 | 1.027 (1.010–1.045) | 0.0007 | 1.029 (1.012–1.046) | <0.0001 |
| Model 4 | Further adjusted for HOMA-IR, based on Model 3 | 1.026 (1.010–1.042) | 0.0009 | 1.028 (1.012–1.044) | <0.0001 |
| Model 5 | Further adjusted for GFR, based on Model 4 | 1.29 (1.013–1.046) | 0.006 | 1.32 (1.018–1.046) | 0.0003 |
| Model 6 | Further adjusted for lipid profiles, based on Model 5 | 1.025 (1.006–1.044) | 0.02 | 1.026 (1.008–1.044) | 0.005 |
Values are ORs (95% CI)
aFor the risk of microalbuminuria, we defined participants with normal urinary albumin excretion as 0 (n=1,539) and microalbuminuria as 1 (n=103), excluding macroalbuminuria (n=14) from the logistic regression analyses
bFor the risk of combined micro- and macroalbuminuria, we defined participants with normal urinary albumin excretion as 0 (n=1,539) and combined micro- and macroalbuminuria as 1 (n=117)