Table III.

Univariate and multivariate analysis of risk factors for overall survival.

				Multivariate analysis
Variable	Patients, n	Recurrence, n	Univariate analysis P-value	Hazard ratio	95% CI	P-value
Presence of hydronephrosis			0.009a	1.587	1.111–2.265	0.011a
Absence	249	52
Presence	271	78
Gender			0.000a	0.604	0.426–0.858	0.005a
Female	291	57
Male	229	73
Age, years			0.005a	1.284	1.068–1.542	0.008a
<50	28	8
50–60	92	17
60–70	175	38
70–80	187	53
≥80	38	14
Preoperative renal function			0.260
No CKD (eGFR≥60)	228	48
Early CKD (60>eGFR≥15)	255	68
End-stage CKD (eGFR<15)	37	14
Urinary cytology			0.385
Negative	116	26
Positive	250	73
Missing data	155	31
Surgical approach			0.503
Open	348	96
Laparoscopic	172	34
Tumor architecture			0.015a			0.262
Papillary	419	100
Sessile	101	30
Multifocality			0.271
No	412	106
Yes	108	24
Location			0.110
Ureter	256	69
Pelvis	264	61
Tumor stage			0.000a	1.581	1.265–1.976	0.000a
Ta	30	4
T1	150	19
T2	202	57
T3	135	48
T4	3	2
Node stage			0.519
N0	52	11
Nx	458	116
N+	10	3
Tumor grade			0.005a			0.133
G1	19	0
G2	310	70
G3	191	60
Tumor necrosis			0.137
No	466	115
Yes	54	15
Tumor size, cm			0.306
≤3	313	76
>3	207	54
CIS			0.344
Absent	504	127
Present	16	3
Adjuvant therapy			0.648
No	485	119
Yes	30	9

^aStatistically significant. CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; CIS, carcinoma in situ.