Table 6.
Association of IL-23R polymorphisms and pulmonary infiltration and cavitary formation in pulmonary TB patients
| dbSNP ID/ | Genotype | Cavitary formation (N = 250) | OR (95 % CI) | Pulmonary infiltration (N = 250) | OR (95 % CI) | ||
|---|---|---|---|---|---|---|---|
| No Cavity lesion | Cavity lesion | ≤ 1/3 of one lung | >1/3 of one lung | ||||
| N = 179 n (%) | N = 71 n (%) | N = 138 n (%) | N = 112 n (%) | ||||
| rs1884444 | TT | 88 (49.2) | 15 (21.1) | 1 | 58 (42.0) | 45 (40.2) | 1 |
| GG + GT | 91 (50.8) | 56 (78.9) | 3.61 (1.90–6.85) | 80 (58.0) | 67 (59.8) | 1.08 (0.65–1.79) | |
| rs10889664 | CC | 87 (48.6) | 36 (50.7) | 1 | 68 (49.3) | 55 (49.1) | 1 |
| TT + CT | 92 (51.4) | 35 (49.3) | 0.92 (0.53–1.59) | 70 (50.7) | 57 (50.9) | 1.01 (0.61–1.66) | |
| rs11465788 | TT | 74 (41.3) | 31 (43.7) | 1 | 57 (41.3) | 48 (42.9) | 1 |
| CC + CT | 105 (58.7) | 40 (56.3) | 0.91 (0.52–1.59) | 81 (58.7) | 64 (57.1) | 0.94 (0.57–1.55) | |
| rs7518660 | GG | 7 (4.1) | 5 (7.0) | 1 | 7 (5.1) | 5 (4.5) | 1 |
| AA + AG | 172 (95.9) | 66 (93.0) | 0.54 (0.17–1.75) | 131 (94.9) | 107 (95.5) | 1.14 (0.35–3.71) | |
| rs11465802 | CC | 72 (40.2) | 30 (42.3) | 1 | 56 (40.6) | 46 (41.1) | 1 |
| AA + AC | 107 (59.8) | 41 (57.7) | 0.92 (0.53–1.61) | 82 (59.4) | 66 (58.9) | 0.98 (0.59–1.63) | |
| rs10889677 | AA | 39 (21.8) | 14 (19.7) | 1 | 31 (22.5) | 22 (19.6) | 1 |
| CC + AC | 140 (78.2) | 57 (80.3) | 1.13 (0.57–2.25) | 107 (77.5) | 90 (80.4) | 1.19 (0.64–2.19) | |
| CNV | CN = 2 | 144 (80.4) | 56 (78.9) | 1 | 109 (79.0) | 91 (81.3) | 1 |
| CN = 1, 3, 4 | 35 (19.6) | 15 (21.1) | 1.10 (0.56–2.17) | 29 (21.0) | 21 (18.7) | 0.87 (0.46–1.62) | |
OR odds ratio, CI confidence interval