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. 2015 Dec 1;15:423. doi: 10.1186/s12906-015-0950-7

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© Tung et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The pathological histology of the EtOAc fraction and its derived phytochemicals of R. oldhamii leaf extract in PO-induced hyperuricemic mice. The H&E staining showed that PO-induced kidney injury caused renal tubular epithelial nuclear condensation (karyopyknosis) in the cortex or the appearance of numerous hyaline casts in the medulla areas. The levels of renal tubular epithelial nuclear condensation or numerous hyaline casts were significantly reduced by benzbromarone, the EtOAc fraction, (2R, 3R)-astilbin, hyposide, guaijaverin, and quercitrin treatments