Table 2.

Haplotype frequencies and molecular diversity of the six Sahelian samples in a 1,396 bp sequence encompassing the NAT2 coding exon

		Population1
Haplotype	Acetylation activity2	FBAN	FTIN	FADE	FBON	DAZ	KANE	Total
NAT2*4	fast	2	4	6	8	7	2	29
NAT2*4a	fast						1	1
NAT2*12A	fast	6	5		4	11	6	32
NAT2*13A	fast	11	10	8	7	2	2	40
NAT2*5A	slow		1		1		3	5
NAT2*5B	slow	39	46	42	47	28	40	242
NAT2*5Ba 3	slow			2	1		1	4
NAT2*5C	slow	3	4	6	2	1	3	19
NAT2*6A	slow	32	17	20	23	23	25	140
NAT2*6Aa 3	slow					1		1
NAT2*6C	slow				1			1
NAT2*7B	slow		1		2	2	2	7
NAT2*14A	slow	2	4	7		1		14
NAT2*14B	slow	3	5	2	2	1	5	18
NAT2*14Ba 3	slow			1				1
NAT2*6F	unknown		1					1
NAT2*6O	unknown					1	1	2
NAT2*12H	unknown			2	1	4	7	14
NAT2*12N 4	unknown		1					1
NAT2*13D 4	unknown				1			1
NAT2*14K 4	unknown		1					1
Total (2N chromosomes)		98	100	96	100	82	98	574
Number of haplotypes (k)		8	13	10	13	12	13
Number of segregating sites (S)		6	9	9	10	10	11
Gene diversity (expected heterozygosity, h)		0.72	0.75	0.75	0.72	0.78	0.76
Nucleotide diversity (π) x 10−3		1.81	1.79	1.85	1.78	1.83	1.93
Tajima’s D (P-value)5		2.65 (0.994)	1.09 (0.875)	1.18 (0.891)	0.73 (0.801)	0.72 (0.799)	0.68 (0.875)

¹Population codes as in Table 1

²Reported activity in the official NAT2 gene nomenclature (nat.mbg.duth.gr)

³Small caps alphabetical suffixes were added to the names of haplotypes that differ from known haplotypes in the flanking region of the NAT2 coding exon (see text)

⁴New haplotypes submitted to the official NAT2 gene nomenclature and included in it (see text)

⁵ P-value associated with Tajima’s D test for departure from selective neutrality: it is given as the proportion of random D values generated under the neutral equilibrium model that are smaller than, or equal to the observed value. The sole significant result is shown in bold; it corresponds to a type I error rate of 0.006, and it remains significant after Bonferroni correction for multiple testing