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. 2015 Dec 1;15:942. doi: 10.1186/s12885-015-1951-0

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© Mitsui et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CYP1B1 expression in RCC cell lines and tissues. a Representative immunoblot displaying CYP1B1 expression in normal kidney (NK) sample, Caki-1, Caki-2, A498, ACHN, 786-O and 769-P. CYP1B1 protein was up-regulated in RCC cell lines in comparison with that of NK. b Representative immunostaining of CYP1B1 in clinical sample obtained from tissue microarray. (a) Weak cytoplastic staining of CYP1B1 was observed in the normal renal tubules. (b) Strong cytoplasmic staining of CYP1B1 was observed in clear cell RCC tumors. (c) CYP1B1 overexpression was also observed in chromophobe RCC tumors. (d) CYP1B1 staining score in clinical samples. CYP1B1 protein expression in RCC samples was significantly higher than that of normal kidney tissues . **, P < 0.01