Figure 1. Flowchart of participants.

¹Acceptable leg channel data was defined as those studies with acceptable signal quality on the leg sensors for >=75% of sleep time.

²Apnea Hypopnea Index at >=3% desaturation level.

³Cases were selected from those with incident CVD over 6 years of follow-up, defined as coronary heart disease (CHD), peripheral vascular disease (PVD), or Cerebrovascular disease (CER): CHD: Acute myocardial infarction, coronary artery bypass surgery, ischemic congestive heart failure, mechanical coronary revascularization, non ST-elevation myocardial infarction, ST-elevation myocardial infarction, hospitalization for unstable angina, sudden CHD death, other CHD event. PVD: Acute arterial dissection, acute arterial occlusion, acute arterial rupture, vascular surgery. CER: Stroke, TIA.

⁴Controls were selected from those without incident CVD or incident deep vein thrombosis, pulmonary embolus, sudden death not specified, or other CVD event not classified above.

⁵Those not considered are men without incident CVD but had incident deep vein thrombosis, pulmonary embolus, sudden death not specified, or other CVD event not classified above.

⁶Twenty-five PSG recordings selected for the case-control study were unable to be read due to lost file, could not open file, no sleep staging scored, etc.