Fig. 1.

Dosing schedule. Tivozanib was administered once daily for 3 weeks, followed by a 1-week break (4 weeks = 1 cycle), and temsirolimus was administered weekly starting on day 8 of cycle 1. Treatment continued for a minimum of 8 weeks (two cycles), but could be continued for up to 1 year for patients achieving response or stable disease. T, temsirolimus.