Table 1.
Dose escalation.
| Dose level | Tivozanib, mg/d |
Temsirolimus, mg/week |
Patients enrolled, n |
|---|---|---|---|
| 1 | 0.5 | 15 | 5 |
| 2 | 1.0 | 15 | 4 |
| 3 | 1.5 | 15 | 3 |
| 4 | 1.5 | 25 | 3 |
| RP2D expansion | 1.5 | 25 | 12 |
RP2D, recommended phase II dose.
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