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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Eur J Cancer. 2013 May 28;49(13):2841–2850. doi: 10.1016/j.ejca.2013.04.019

Table 5.

Pharmacokinetic Parameters of Temsirolimus and Sirolimus at day 22

Parameter, mean (SD) Temsirolimus 15 mg/week Temsirolimus 25 mg/week
Temsirolimus
   Evaluable, n 7 9
   Cmax, ng/mL 164.3 (88.1) 199.6 (33.4)
   Tmax, h 2.32 (1.20) 1.81 (0.54)
   AUC0–last, h•ng/mL 3191 (1925) 4245 (2033)
Sirolimus
   Evaluable, n 7 9
   Cmax, ng/mL 51.33 (25.44) 93.79 (25.04)
   Tmax, h 3.18 (1.34) 1.81 (0.54)
   AUC0–last, h•ng/mL 3559 (1629) 6566 (4110)
Ratio of sirolimus AUC0–last /temsirolimus AUC0–last 1.26 (0.67) 1.48 (0.66)

SD, standard deviation; Cmax, maximum serum concentration; Tmax, time to maximum concentration; AUC0–last, area under the concentration– time curve from time 0 to the last non-zero concentration value.