TABLE 2.

Primary and secondary pharmacokinetic endpoints

Pharmacokinetic endpoint	Definition
Primary endpoints
AUC(0-t)	AUC from time 0 to the last sampling time
AUC(0-inf)	AUC from time 0 to infinity
Cmax	Maximal concentration
Secondary endpoints
AUC% extrap obs	Percentage of AUC extrapolated to infinity from Tlast to infinity based on observed value for concentration at Tlast
Kel	Elimination rate constant
t1/2	Terminal elimination half-life
tmax	Time to reach peak plasma concentration

AUC, area under the plasma concentration–time curve.