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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Eur J Med Chem. 2014 Sep 8;86:714–723. doi: 10.1016/j.ejmech.2014.09.023

Scheme 2.

Scheme 2

Synthesis of Compounds (6a–6g). i) EtOH, H2SO4,100 °C, 12 h. ii) Pd2(dba)3, P(Cy)3, Na2CO3, 4:1 DMF/H2O, MWI 130 °C, 30 min. iii) Chloroacetaldehyde, Na2CO3, EtOH, 100 °C, 48 h. iv) LiOH, 1:1 THF/H2O, 100 °C, 5 h. v) EDC, HOAt, DIPEA, DMF, rt.