Table 2.
Metabolic parameters in 8-week-old mice (Based on Sugimoto et al. [15].)
| n | NC | NCM | HF | HFM | |
|---|---|---|---|---|---|
| Body weight (g) | 10–11 | 21.5 ± 0.2 | 22.2 ± 0.2 | 27.3 ± 0.4 *, ** | 25.8 ± 0.4 *, **, *** |
| HOMA-R | 5 | 1.4 ± 0.3 | 1.1 ± 0.3 | 8.4 ± 1.3 *, ** | 4.0 ± 0.7 *, **, *** |
| Weight of epididymal white adipose tissue (g) | 9–14 | 0.27 ± 0.02 | 0.28 ± 0.01 | 1.1 ± 0.08 *, ** | 0.85 ± 0.04 *, **, *** |
| Weight of subcutaneous white adipose tissue (g) | 6 | 0.3 ± 0.03 | Not measured | 1.5 ± 0.15 * | 0.98 ± 0.12 *, *** |
| Active glucose-dependent insulinotropic peptide (GIP) (pg/mL) | 9–15 | 28.2 ± 3.6 | 20.4 ± 2.5 | 38.8 ± 4.7 ** | 32.0 ± 4.3 |
| Active glucagon-like peptide 1 (GLP1) (pg/mL) | 8–9 | 54.8 ± 7.9 | 61.1 ± 4.9 | 66 ± 7.5 | 76.9 ± 14.4 |
| Concentration of miglitol (μmol/L) | 3–4 | Not measured | 0.06 ± 0.02 | Not Measured | 0.26 ± 0.13 |
* p < 0.05 vs NC; ** p < 0.05 vs NCM; *** p < 0.05 vs HF
Values are means ± SE for 3–15 mice. Four-week-old male C57BL/6 J mice were divided into 4 groups: a control group (NC), which was fed normal chow; a normal chow plus miglitol (NCM) group, which was fed the normal chow plus miglitol; a high fat (HF) group, which was fed the high fat diet; and a high fat plus miglitol (HFM) group, which was fed the high fat diet plus miglitol. At 8 weeks the samples were collected under fasting conditions. Repeated-measures analysis of variance (ANOVA) with Tukey-Kramer post-hoc comparisons were performed for multiple comparisons