Table 4.

Results of the gene and gene–environment interaction analysis for the SNPs with maternal cognitive sensitivity on theory of mind

	FBAT	QBAT			QBAT-E
SNP	P-value	β [95% CI]	Z	P-value	β [95% CI]	Z	P-value
rs2254298
G	0.836	−0.14 [−0.16, 0.35]	−0.54	0.582	0.54 [−1.26, 2.34]	0.59	0.557
A		−0.07 [−0.64, 0.50]	−0.24	0.807	0.06 [−0.35, 0.47]	0.29	0.770
rs11131149
G	0.079*	0.15 [−0.32, 0.62]	0.63	0.534	0.65** [0.12, 1.18]	2.36**	0.019**
A		0.10 [−0.43, 0.63]	0.37	0.716	−0.99** [−1.81, −0.17]	−2.39**	0.017**
rs237897
G	0.243	0.27 [−0.08, 0.62]	1.50	0.133	−0.08 [−0.53, 0.37]	−0.35	0.719
A		−0.62 [−1.87, 0.63]	−0.41	0.134	0.25 [−1.81, 2.31]	0.24	0.814
rs237899
G	0.301	−0.51 [−1.24, 0.22]	−1.39	0.164	−0.25 [−4.15, 3.65]	−0.13	0.899
A		0.35 [−0.18, 0.88]	1.27	0.204	0.04 [−0.35, 0.43]	0.20	0.856

*P < 0.10. **P < 0.05.

SNP, single nucleotide polymorphism; FBAT, P-value for the FBAT statistic; FBAT, test for the main genetic effect in the model modeling only the main genetic effect (not the interaction). This is the primary test statistic for examining genetic associations in family-based designs. It is a generalization of the Transmission Disequilibrium Test method, in which alleles transmitted to affected offspring are compared with the expected distribution of alleles among offspring based on Mendel’s law of segregation.

QBAT, test for the main genetic effect in the gene–environment interaction model.

QBAT-E, test for the gene–environment interaction in the gene–environment interaction model.

β (95% CI), coefficient in the model for the main effect (QBAT) and gene–environment interaction (QBAT-E), and the 95% confidence interval; Z – [β/SE(β)], the value of the test statistic.