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. 2015 Dec 1;26(24):4333–4346. doi: 10.1091/mbc.E15-06-0422

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© 2015 Gong, Renigunta, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Identifying loci in the claudin-16 transmembrane domain important for its interaction with claudin-19. (A) Helical-wheel view of the four TM domains in claudin-16. The positions of alanine insertion are labeled with arrows. (B, C) Effects of alanine insertion into claudin-16 TM domains on the claudin-16 and -19 interaction assayed with the Y2H β-gal reporter gene. The loci with β-gal reporter activity <20% of wild-type interaction level are labeled with asterisks.