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. 2015 Dec 1;26(24):4412–4426. doi: 10.1091/mbc.E15-02-0087

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© 2015 Li et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Model for the GGA3-mediated recycling of TrkA. After NGF stimulation, TrkA is internalized in early endosomes. In parallel, Arf6 is activated by TrkA through Src and recruits GGA3 to the endosomal membrane, where GGA3 directly binds to a DXXLL motif in TrkA or aids in retaining a GGA3-TrkA complex in endosomal recycling membrane. This interaction promotes the sorting of TrkA to the recycling pathway, leading to sustained activation of Akt and cell survival.