Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 1;26(24):4478–4491. doi: 10.1091/mbc.E15-06-0415

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Binukumar et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

“ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

PMC Copyright notice

FIGURE 5: — TP5 suppresses MPTP-induced astroglial and microglial activation and inflammation in the SN in vivo. (A) Sections of SN tissues obtained from the same animals as used in Figure 3 were immunostained with GFAP antibody for astrocyte and Cdllb (C) for microglia. The heightened expression of GFAP and CdIIb was observed in the MPTP group as compared with the control group, whereas the MPTP group treated with TP5 reveals a moderate staining of Cd11b and GFAP. The control group, however, shows almost negligible staining. Scale bar, 200 mm. (B) Western blots of tissue lysates from each group show a marked reduction in the expression of MPTP-induced GFAP by TP5. In addition, sandwich ELISAs of lysates from each group also show a TP5 rescue of overexpressed TNF-α (D) and IL-1β (E) in MPTP-induced inflammation (n = 8, ***p < 0.001, **p < 0.01).