FIGURE 6:

TP5 improved locomotor functions in MPTP-treated mice. (A) Sixteen hours after standard protocol treatment, the four groups of mice were assessed for spontaneous motor activity in a novel environment (open field) for 10 min, as described in Materials and Methods. Compared to controls, MPTP-treated mice initiated less spontaneous locomotor activity than saline control. After TP5 treatment mice, displayed a significant improvement in motor activity. (B) Individual movement components were analyzed as shown in the bar graphs. TP5-treated animals showed only a modest improvement in distance run and horizontal activity (*p < 0.05), whereas vertical activity was robustly improved (***p < 0.001). Resting time also was affected by TP5 treatment (**p < 0.01). Data are means ± SEM for 8–10 mice/group. Statistical significance was assessed by one-way repeated-measures analysis of variance with Bonferroni post hoc test.