Table 1.
PK/PD analysis of marbofloxacin with the parameter of Cmax/MIC and Cmax/MPC against H. parasuis
| Parameter (units) | Value |
|---|---|
| Log Emax (cfu/mL) | 6.8 |
| Log E0 (cfu/mL) | 1.2 |
| Cmax/MIC EC50 | 5.6 |
| Cmax/MIC (bacteristasis) | 3 |
| Cmax/MIC (bactericidal) | 6.5 |
| Cmax/MIC (bacteria elimination) | 8 |
| Cmax/MPC (bactericidal) | 2.5 |
| Cmax/MPC (bacteria elimination) | 3 |
| Slope (N) | 3.2 |
Note: E 0 is the change in log10 cfu/mL after 24 h incubation in the control sample compared with the initial inoculum. Emax is the difference in effect between the greatest amount of growth (as seen for the growth control, E0) and the greatest amount of kill. EC50 is the Cmax/MIC value producing a 50 % reduction in bacterial counts from the initial inoculum, and N is the Hill coefficient that describes the steepness of the dose–response curve