TABLE 2.
Associations between EGFR/KRAS mutations and histologic subtypes
| Histologic subtype | Total | Mutation, n (%)
|
||
|---|---|---|---|---|
| Wild-type | EGFR | KRAS | ||
| Mucinous subtypes | 42 | 18 (43) | 0 (0) | 24 (57) |
| Mucinous AIS | 0 | 0 (0) | 0 (0) | 0 (0) |
| Mucinous MIA | 1 | 0 (0) | 0 (0) | 1 (100) |
| Invasive mucinous | 36 | 14 (39) | 0 (0) | 22 (61) |
| Colloid | 5 | 4 (80) | 0 (0) | 1 (20) |
| Non-mucinous subtypes | 822 | 491 (60) | 127 (15) | 204 (25) |
| Nonmucinous AIS | 2 | 1 (50) | 0 (0) | 1 (50) |
| Nonmucinous MIA | 31 | 22 (71) | 4 (13) | 5 (16) |
| Lepidic | 97 | 49 (50) | 27 (28) | 21 (22) |
| Acinar | 300 | 180 (60) | 54 (18) | 66 (22) |
| Papillary | 151 | 76 (50) | 29 (19) | 46 (30) |
| Micropapillary | 78 | 49 (63) | 7 (9) | 22 (28) |
| Solid | 163 | 114 (70) | 6 (4) | 43 (26) |
| Total | 864 | 509 (59) | 127 (15) | 228 (26) |
EGFR, epidermal growth factor receptor; AIS, adenocarcinoma in situ;
MIA, minimally invasive adenocarcinoma