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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: Prog Biophys Mol Biol. 2015 Jan 22;117(1):43–58. doi: 10.1016/j.pbiomolbio.2015.01.003

Fig. 8.

Fig. 8

pH changes caused by CO2 influx and major features of the mathematical model of Somersalo et al. (2012). A: Model of acid-base chemistry at the outer surface and inner surface of the plasma membrane as CO2 enters into the cell. B: Representative intracellular (pHi) and surface pH (pHS) transients caused by CO2 influx. These pHi and pHS trajectories are the result of a simulation, and are the same trajectories shown as the blue records in Fig. 11. C: Major components of the mathematical model for a spherical cell with radial symmetry. BECF, bulk extracellular fluid; EUF, extracellular unconvected fluid; ICF, intracellular fluid; k, a rate constant. Panel C is modified from Fig. 2 in Somersalo et al. (2012).