Figure 1.

Two-tier approach to predicting major route of elimination utilizing in vitro permeability rate to determine extent of metabolism and the previously defined logistic regression model to predict major route of elimination of poorly metabolized drugs. ^aLogistic regression model including calculated polarizability and metabolic stability published by Hosey et al.:¹¹ $\mathrm{\Pi }(x)=\frac{1}{e^{-(0.217\mathit{POL}-0.0745\mathit{MetStab}-2.28)}+1}$ When Π(x) >0.237, the drug is predicted to be eliminated in the bile.