Table I.

Area under the receiver operating curve for bootstrapped sampling of measured or predicted permeability rate as a predictor of extensively metabolized and poorly metabolized drugs eliminated primarily as unchanged drug in either the bile or urine.

	Extensive Metabolism vs
In vitro Model	Elimination as unchanged drug (N)	Renal elimination of unchanged drug (N)	Biliary elimination of unchanged drug (N)	Biliary vs Renal
Caco2	0.93±0.07 (11)	0.90±0.11(11)	0.82 (1)	0.53 (1)
MDCK	0.91 ± 0.03 (5)	0.95 ± 0.02 (5)	0.89 (1)	0.53 (1)
PAMPA	0.93 ± 0.05 (6)	0.95 ± 0.04 (6)	---	0.71 (1)
In silico Model
AP MDCK	0.78±0.03	0.82±0.04	0.81±0.05	0.56±0.09
AP Peff	0.74±0.03	0.76±0.04	0.69±0.07	0.58±0.09
VS+ CACO2	0.82±0.03	0.81±0.07	0.87±0.03	0.61±0.10

(N) represents the number of datasets

AP: ADMET Predictor

VS+: VolSurf+