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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Eur J Med Chem. 2015 Feb 28;94:123–131. doi: 10.1016/j.ejmech.2015.02.052

Scheme 2.

Scheme 2

a) 2-chloroacetaldehyde (1.2 eqv.), 1-butanol, 130 °C, 12 h, b) Br-R1, KOAc (2 eqv.), Pd(OAc)2, DMF, MWI 160 °C, 1 h c) B(OH)2-R2, Pd2(dba)3, P(Cy)3, Na2CO3, DMF:H2O (8:1), MWI 130 °C, 1 h d) Br-R1, KOAc (2 eqv.), Pd(OAc)2, DMF, MWI 160 °C, 1 h.