Table 6.
Oncological outcomes and risk factors for cancer specific death after resection of RPR after radical nephrectomy in the literature.
| References | No. Patients | Time of Study | RPR Location | Follow-up (months) | No. Patients who had RPR surgery (%) | Recurrence/Progression (%) | Death from Cancer (%) | NED (%) | 1, 3, 5 Year CSS (%) | Risk Factors for cancer-specific death |
|---|---|---|---|---|---|---|---|---|---|---|
| Current study | 102 | 1990-2014 | RPR | 32 | 102 (100) | 60 (58.8) | 33 (32.4) | 40 (39.2) | 92, 71, 52 | †N-stage, recurrent tumor size |
| *Russell et al.27 | 22 | 1993-2012 | LN | 22.3 | 22 (100) | 10 (45%) | 2 (9) | 12 (54.5) | NA | NA |
| *Paparel et al.26 | 72 | Not specified | RPR | 26.4 | 46 (66) | NA | 28 (38) | 12 (17) | 74, 55, 46 | Time to recurrence, surgical resection of RPR |
| Margulis et al.9 | 54 | 1990-2007 | RPR | 41 | 54 (100) | 35 (65) | 23 (43) | 11 (20) | NA | †Positive surgical margin at RPR resection, recurrent tumor size, LDH |
| Master et al.17 | 14 | 1990-2003 | Soft tissue | 34 | 14 (100) | 9 (64) | 9 (64) | NA | 86, 40, 30 | NA |
| Schrodter et al.10 | 13 | 1991-2000 | Soft tissue | 36.9 | 13 (100) | 8 (61) | 7 (54) | 5 (38) | NA ,56, NA | Time to recurrence, recurrent tumor size |
| Itano et al.7 | 30 | 1970-1998 | Soft tissue | 39 | 10 (33) | 8 (80) | 25 (83) | 2 (20) | 66, 40, 28 | Surgical resection of RPR |
| Sandhu et al.6 | 16 | 1994-2004 | RPR | 12 | 14 (87) | 11 (68) | 5 (36) | 5 (31) | NA | NA |
| Bruno et al.28 | 34 | 1989-2004 | RPR | 16.9 | 16 (47) | NA | 26 (76) | 3 (9) | 63, 31,18 | Surgical resection of RPR |
| Boorjian et al.29 | 15 | 1970-2004 | Soft tissue, LN | 18 | 15 (100) | 10 (67) | 6 (40) | 5 (33) | **65, 35 | NA |
| Tanguay et al.30 | 16 | 1983-1994 | Soft tissue | 23.5 | 16 (100) | 10 (62) | 4 (25) | 6 (38) | NA | NA |
| Esrig et al.8 | 11 | 1973-1990 | Soft tissue | NA | 10 (91) | 7 (63) | 4 (36) | 4 (36) | 55, 36, NA | NA |
*
Multi-institutional study
**
CSS (%) at 2 and 4 years respectively
†
Multivariate Cox regression analysis (vs Univariate Cox regression analysis)
Retroperitoneal recurrence (RPR) defined as soft tissue, ipsilateral adrenal gland, ipsilateral lymph nodes (LN)
NA, not applicable
NED, no evidence of disease