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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Med Chem. 2013 Apr 23;56(13):5219–5230. doi: 10.1021/jm3017706

Figure 1.

Figure 1

Post-translational processing of RAS proteins. Farnesyltransferase (FTase) catalyzes the transfer of a farnesyl group to the terminal cysteine of new synthesized RAS proteins. Next, the three C-terminal amino acids are cleaved by the endopeptidase RAS-converting enzyme 1 (RCE1). Carboxymethylation of of the terminal cysteine residue is accomplished by isoprenylcysteine carboxylmethyltransferase 1 (ICMT1). Finally, palmitoyl transferase (PTase) transfers a palmitoyl group to C-terminal cysteine residues of HRAS, NRAS, and the KRAS-4A isoform.