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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Med Chem. 2013 Apr 23;56(13):5219–5230. doi: 10.1021/jm3017706

Figure 3.

Figure 3

Downstream signaling of RAS. Ras interacts with a number of downstream effectors. The main ones include RAF protein kinases, phosphoinositide 3-kinases (PI3Ks), guanine nucleotide exchange factors for the RAS-related protein Ral (RalGDS), and phospholipase Cε (PLCε).