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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Med Chem. 2013 Apr 23;56(13):5219–5230. doi: 10.1021/jm3017706

Figure 7.

Figure 7

(a) Structures of compounds shown to interfere with the KRAS/SOS interaction. (b) Overlay of 8 (pink) and a compound similar to 11 (teal) in the hydrophobic binding pocket of KRAS. Reproduced with permission of D. Erlanson.58