Figure 1.

Neutrophil oxidative burst is impaired in children with sickle cell disease. (A) Representative histogram of rhodamine fluorescence intensity of unstimulated (dark fill) and PMA-stimulated (light fill) neutrophils from a child with sickle cell disease. (B–D) Comparison of unstimulated rhodamine fluorescence intensity (B), PMA-stimulated rhodamine fluorescence intensity (C), and PMA-stimulated upregulation of surface CD11b expression (D), in neutrophils of healthy control (n=25) and sickle cell disease subjects (n=26). The Mann-Witney test was used for all comparisons.