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Putative long-distance interactions in the HIV-1 genome. (A) Core organizing structure (COS) in the central domain of the HIV-1 genome, coordinating the formation of three arms. (B) Putative long-distance interactions in the ‘RRE domain’ of the HIV-1 genome. The letters correspond to those in Figure 1. Base pairs with significant base pair covariations are indicated, in the 5′-3′ direction.
