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. 2015 Nov 5;43(21):10376–10386. doi: 10.1093/nar/gkv1167

Figure 4.

Figure 4.

Thermodynamic profiles (A) and Gibbs free energy contributions (driving forces) (B) of ligand binding to Tel22 at 200 mM concentration of K+ ions and 25 °C. Thermodynamic binding profiles of Phen-DC3 and 360A-Br are presented only for their binding to the high affinity Tel22 binding site (49). Error bars in ΔG° and ΔH° represent 2x standard deviations obtained as square roots of diagonal elements of variance-covariance matrixes obtained from global model analysis of experimental data. Errors in TΔS° were calculated from the errors of ΔG° and ΔH°. The errors in ΔG° contributions were calculated combining the errors of experimental quantities (ΔG°, ΔH°, ΔC°P; global model analysis) and errors reported in the literature (ΔG°hyd, ΔG°rt) (60–62).