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. 2015 Oct 3;43(21):10534–10545. doi: 10.1093/nar/gkv996

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Structural changes induced by tRNA binding. (A) The structural superposition of the free human tRNA^Sec (blue, PDB 3A3A), complexed human tRNA^Sec (orange) and the free mouse tRNA^Sec (green, PDB 3RG5). (B) The backbone alignment of the free hSerRS (green, PDB 3VBB), Ser-SA-bound hSerRS (salmon, PDB 4L87) and tRNA-bound hSerRS in the 2:1 complex (blue). (C) The overlay of the two monomers of the 2:1 complex. There is a 6°-angle rotation in the helical TBD due to the binding of tRNA, while the ADs superimpose well. (D) The overlay of the two monomers of the 2:2 complex. One subunit is in color (tRNA in orange) as in Figure 1A while the other is in gray. (E) The backbone overlay of the ADs of the 2:2 and 2:1 complexes. hSerRS in the 2:2 complex is colored green while in the 2:1 complex is yellow.