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Endogenous factors that contribute to reduced nitric oxide (NO) bioavailability. Reduced NO directly contributes to vascular dysfunction and development of cardiovascular disease. iNOS: inducible NO synthase (NOS); eNOS: endothelial NOS; CAT: cationic amino acid transporter; ADMA: asymmetric dimethylarginine; OxLDL: oxidized low density lipoprotein.
