Table 2.
Changes in serum bile acid profiles after a 3-week treatment period with fenofibrate.
| Before fenofibrate | After fenofibrate | |||||||
|---|---|---|---|---|---|---|---|---|
| Bile acids | Mean | SEM | 10th | 90th | Mean | SEM | 10th | 90th |
| CDCA | 256.9 | 29.5 | 16.4 | 610.9 | 189.2c | 20.8 | 14.2 | 570.1 |
| TCDCA | 92.9 | 8.8 | 12.7 | 268.5 | 103.1 | 9.5 | 15.8 | 242.3 |
| GCDCA | 745.9 | 54.2 | 169.8 | 1,694.2 | 703.8 | 46.4 | 130.5 | 1,656.3 |
| CA | 176.2 | 27.1 | 2.6 | 403.2 | 159.7 | 23.0 | 2.4 | 389.7 |
| TCA | 113.7 | 15.8 | 8.1 | 269.5 | 112.0 | 16.1 | 12.4 | 203.3 |
| GCA | 198.4 | 16.9 | 29.8 | 461.5 | 227.3 | 18.5 | 39.2 | 531.2 |
| UDCA | 106.2 | 7.9 | 13.6 | 269.1 | 73.9c | 5.0 | 10.2 | 166.8 |
| TUDCA | 6.1 | 1.2 | 0.00 | 13.3 | 9.2c | 2.6 | BLQ | 15.1 |
| LCA | 17.6 | 1.3 | 4.4 | 34.3 | 14.3c | 1.3 | 3.2 | 27.7 |
| TLCA | 19.1 | 1.1 | BLQ | 32.3 | 19.9 | 1.1 | BLQ | 32.3 |
| GLCA | 18.4 | 1.7 | 4.6 | 35.0 | 16.9a | 1.9 | 4.6 | 35.9 |
| LCA-S | 7.0 | 0.6 | BLQ | 14.4 | 5.4b | 0.5 | BLQ | 11.0 |
| DCA | 393.1 | 24.6 | 102.9 | 782.4 | 305.6c | 19.4 | 64.6 | 627.0 |
| TDCA | 35.1 | 3.2 | 4.5 | 81.6 | 44.8b | 3.9 | 5.5 | 104.0 |
| GDCA | 275.5 | 19.3 | 62.5 | 625.2 | 252.2 | 18.9 | 45.8 | 539.0 |
| HDCA | 53.5 | 3.0 | 17.4 | 104.5 | 43.2c | 2.3 | 11.8 | 81.8 |
| HCA | 5.5 | 0.5 | BLQ | 13.6 | 7.4c | 0.6 | BLQ | 17.5 |
| Total CDCA | 1,095.7 | 76.5 | 257.3 | 2,414.3 | 996.1 | 59.6 | 213.0 | 2,179.1 |
| Total CA | 488.2 | 40.4 | 74.6 | 1,245.4 | 499.0 | 38.5 | 82.3 | 1,197.3 |
| Total DCA | 703.7 | 40.4 | 201.8 | 1,465.3 | 602.6c | 36.2 | 140.5 | 1,217.1 |
| Total LCA | 62.0 | 3.2 | 14.6 | 106.2 | 56.5a | 3.2 | 12.6 | 98.8 |
| Total primary | 1,583.9 | 109.4 | 354.1 | 3,504.5 | 1,495.1 | 89.4 | 310.8 | 3,312.4 |
| Total secondary | 765.7 | 42.6 | 241.6 | 1,566.6 | 659.2c | 38.1 | 197.3 | 1,313.4 |
| Total 6α-hydroxy | 59.0 | 3.1 | 21.6 | 110.1 | 50.6c | 2.4 | 16.0 | 91.4 |
| Total free | 1,009.1 | 74.3 | 252.8 | 2,056.6 | 793.3c | 55.2 | 168.0 | 1,685.2 |
| Total glyco | 1,238.1 | 84.4 | 318.1 | 2,536.7 | 1,200.3 | 77.1 | 264.6 | 2,551.5 |
| Total tauro | 266.7 | 25.7 | 35.7 | 747.9 | 288.9 | 27.5 | 50.0 | 606.1 |
| TOTAL | 2,520.9 | 142.5 | 795.1 | 5,015.2 | 2,287.9 | 116.9 | 774.3 | 4,434.6 |
Bile acid concentrations are expressed in nM. Statistically significant differences in bile acid concentrations were determined by the Wilcoxon matched-pairs signed-ranks test: a, p<0.05; b, p<0.01; c, p<0.001.
BLQ, below the limit of quantification. CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCDCA, glycochenodeoxycholic acid; GCA, glycocholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; HCA, hyocholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; LCA-S, LCA-sulfate; TCDCA, taurochenodeoxycholic acid; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid; TOTAL, sum of all bile acids.