Table 3. P-values of top 2 significant pathways with rare variants associated with EOMI.
| Name of pathway | VEGF signaling pathway | TGFβ signaling pathway |
|---|---|---|
| Number of genes | 68 | 17 |
| EA | ||
| SFPCA | 7.26E-06 | 2.00E-05 |
| FPCA | 4.17E-03 | 8.30E-04 |
| LCT/LCT | 3.41E-01 | 6.93E-03 |
| QT/QT | 6.96E-01 | 5.51E-02 |
| DT/DT | 2.45E-01 | 3.92E-01 |
| WSS/Fisher exact | 1.18E-02 | 2.87E-01 |
| VT/Fisher exact | 2.37E-01 | 4.75E-02 |
| CMC/Fisher exact | 4.81E-01 | 5.79E-02 |
| CMC | 7.40E-01 | 8.94E-01 |
| SKAT | 4.07E-02 | 2.44E-03 |
| GSEA | 7.40E-01 | 7.04E-02 |
| PCA | 4.40E-03 | 1.20E-03 |
| AA | ||
| SFPCA | 2.85E-01 | 9.04E-05 |
| FPCA | 3.32E-01 | 5.48E-04 |
| LCT/LCT | 4.09E-01 | 4.28E-02 |
| QT/QT | 1.11E-01 | 1.09E-01 |
| DT/DT | 6.20E-01 | 1.91E-01 |
| WSS/Fisher exact | 2.04E-01 | 2.61E-01 |
| VT/Fisher exact | 3.98E-01 | 2.62E-01 |
| CMC/Fisher exact | 5.45E-02 | 1.99E-02 |
| CMC | 1.73E-01 | 4.68E-02 |
| SKAT | 1.25E-01 | 1.72E-02 |
| GSEA | 1.02E-01 | 6.06E-02 |
| PCA | 8.70E-01 | 3.20E-02 |
Abbreviations: AA, African origin; CMC, combined multivariate and collapsing; DT, de-correlation test; EE, European origin; EOMI, early-onset myocardial infarction; FPCA, functional principal component analysis; LCT, linear combination test; QT, quadratic test; SFPCA, smoothed functional principal component analysis; VEGF, vascular endothelial growth factor; VT, variable-threshold; WSS, weighted sum.