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. 2015 Dec 1;10(12):e0142868. doi: 10.1371/journal.pone.0142868

Table 1. Correlation between demography and histopathology with recurrence.

CKC, cold knife conization; LEEP, loop electrosurgical excision procedure; CIN, cervical intraepithelial neoplasia; HPV, human papilloma virus.

Variable No recurrence (n = 452) Recurrence (n = 50) P value
Age (median and range) 39 (21–71) 38 (21–62) 0.844 a
Menopause 0.783 b
Yes 23 (5.1%) 3 (6%)
No 429 (94.9%) 47 (94%)
Parity (median and range) 1 (0–3) 1 (0–3) >0.99 a
Conization method 0.454 b
LEEP 148 (32.7%) 19 (38%)
CKC 304 (67.3%) 31 (62%)
Cone depth (mm) 0.049 b
≤18 162 (35.8%) 25 (50%)
>18 290 (64.2%) 25 (50%)
Punch biopsy 0.325 b
CIN1 29 (6.4%) 3 (6%)
CIN2 154 (34.1%) 12 (24%)
CIN3 269 (59.5%) 35 (70%)
High risk HPV 0.289 b
Yes 412(91.2%) 48 (96%)
No 40 (8.8%) 2(4%)
Colposcopy adequacy 0.227 b
Yes 354 (78.3%) 35 (70%)
No 98 (21.7%) 15 (30%)
Cone pathology 0.271 b
Normal 54 (11.9%) 3 (6%)
CIN1 67(14.8%) 6 (12%)
CIN2 105(23.2%) 9 (18%)
CIN3 226 (50%) 32 (64%)
Surgical margins <0.001 b
Negative 402 (97.1%) 38 (82.6%)
Positive 12 (2.9%) 8 (17.4%)
Follow-up (months, median, range) 34 (12–94) 12 (1–55)

a Pearson Chi-square test.

b Mann-Whitney U test.