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. 2015 Dec 1;11(12):e1005693. doi: 10.1371/journal.pgen.1005693

Fig 6. Model of Trim33 function at active RLTR10B retrotransposons in the testis.

Fig 6

An RLTR10B element that acts as an alternative promoter of a nearby gene is shown. A-Myb recruits RNA Pol II and drives transcription. Trim33, acting as an E3 ubiquitin ligase, ubiquitinates and destabilises A-Myb, resulting in decreased expression of the locus.