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. 2015 Dec 1;10(12):e0143897. doi: 10.1371/journal.pone.0143897

Table 1. MPN Patient characteristics.

Patient Diagnosis Gender Age at diagnosis JAK2V617F mutation Response to Vorinostat Response to Ruxolitinib
1 AML (Post-PV) F 64 positive ++ ++
2 PV F 60 positive ++ n.d.
3 AML F 55 negative +++ ++
4 ET M 38 negative + +
5 MPN-U M 45 negative + -
6 ET F 72 negative +++ +
7 AML (Post-PV) M 76 positive ++ +
8 MPN-CEL/HES F 23 negative ++ +
9 PV F 52 negative ++ -

AML–Acute Myeloid Leukaemia; PV–Polycythaemia Vera; ET–Essential Thrombocytosis; MPN-U—Myeloproliferative Neoplasm–Unclassified; MPN-CEL/HES—Myeloproliferative Neoplasm with chronic eosinophilic leukemia/hypereosinophilic syndrome; F–Female; M–Male; n.d.–not determined; Response to Vorinostat and to Ruxolitinib–these represent the Viability Index (VI) of Lin-CD34+ patients cells treated with Vorinostat and Ruxolitinib without stroma (- →1.00>VI>0.91; + → 0.90>VI>0.51; ++ → 0.50>VI>0.21 and +++ → 0.20>VI>0.00).