Table 1. MPN Patient characteristics.
Patient | Diagnosis | Gender | Age at diagnosis | JAK2V617F mutation | Response to Vorinostat | Response to Ruxolitinib |
---|---|---|---|---|---|---|
1 | AML (Post-PV) | F | 64 | positive | ++ | ++ |
2 | PV | F | 60 | positive | ++ | n.d. |
3 | AML | F | 55 | negative | +++ | ++ |
4 | ET | M | 38 | negative | + | + |
5 | MPN-U | M | 45 | negative | + | - |
6 | ET | F | 72 | negative | +++ | + |
7 | AML (Post-PV) | M | 76 | positive | ++ | + |
8 | MPN-CEL/HES | F | 23 | negative | ++ | + |
9 | PV | F | 52 | negative | ++ | - |
AML–Acute Myeloid Leukaemia; PV–Polycythaemia Vera; ET–Essential Thrombocytosis; MPN-U—Myeloproliferative Neoplasm–Unclassified; MPN-CEL/HES—Myeloproliferative Neoplasm with chronic eosinophilic leukemia/hypereosinophilic syndrome; F–Female; M–Male; n.d.–not determined; Response to Vorinostat and to Ruxolitinib–these represent the Viability Index (VI) of Lin-CD34+ patients cells treated with Vorinostat and Ruxolitinib without stroma (- →1.00>VI>0.91; + → 0.90>VI>0.51; ++ → 0.50>VI>0.21 and +++ → 0.20>VI>0.00).