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. 2015 Dec 1;10(12):e0143802. doi: 10.1371/journal.pone.0143802

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© 2015 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 6 — The TGF-β signaling pathway increases Fn14 expression through SMAD4 binding to the Fn14 promoter in human dermal fibroblasts. Then, upregulated Fn14 expression promotes ECM synthesis and fibroblast activation.