Table 3. Genome-wide significant signals for each endophenotype.
P-values, chromosomal and gene location are presented for each signal from the meta-analyses (Meta) and from the individual (ADNI) and (TARCC) cohorts. P-values are also shown for the association between each endophenotypic signal and age of onset (AOO) and case-control status (CC).
| Trait | Trait Chromosome | SNP(s) | P-value (TARCC) | P-value (ADNI) | P-value (Meta) | P-value (AOO) | P-value (CC) | SNP Chromosome | SNP Genes |
|---|---|---|---|---|---|---|---|---|---|
| ADN | 3 | chr3:186558403 | 9.56E-04 | 8.99E-06 | 3.16E-08 | 0.4903 | 0.4992 | 3 | MAP3K13 |
| chr3:186562865 | 2.93E-04 | 2.94E-05 | 3.75E-08 | 0.4983 | 0.5105 | ||||
| rs57056768 | 7.40E-04 | 1.97E-05 | 5.53E-08 | 0.5121 | 0.5265 | ||||
| chr3:186552158 | 1.02E-02 | 2.85E-05 | 9.52E-07 | 0.5367 | 0.4756 | ||||
| rs8111139 | 1.79E-05 | 9.47E-04 | 2.21E-07 | 0.0026 | 0.9600 | 19 | ZNF320 | ||
| F7 | 13 | rs561241 | 1.64E-02 | 7.96E-06 | 1.09E-08 | 0.4981 | 0.3392 | 13 | F7 |
| rs3093233 | 1.60E-02 | 2.39E-04 | 1.78E-08 | 0.7954 | 0.2682 | ||||
| rs6039 | 1.63E-02 | 2.24E-04 | 1.87E-08 | 0.7902 | 0.2739 | ||||
| rs2480953 | 1.55E-02 | 1.97E-04 | 2.38E-08 | 0.8831 | 0.2627 | ||||
| rs9670535 | 1.57E-02 | 2.55E-04 | 2.67E-08 | 0.8743 | 0.2589 | ||||
| rs9669828 | 1.57E-02 | 2.49E-04 | 2.71E-08 | 0.8786 | 0.2652 | ||||
| rs9670502 | 1.57E-02 | 2.60E-04 | 3.03E-08 | 0.9689 | 0.9067 | ||||
| rs1046205 | - | 4.99E-08 | 4.99E-08 | 0.0141 | 0.5717 | ||||
| rs3093253 | 5.94E-05 | 6.67E-05 | 1.65E-07 | 0.5414 | 0.4311 | ||||
| rs569557 | 6.36E-06 | 1.46E-05 | 2.67E-07 | 0.5899 | 0.4263 | ||||
| rs2774033 | 3.71E-04 | 1.41E-05 | 2.75E-07 | 0.5621 | 0.4167 | ||||
| rs493833 | 3.96E-04 | 2.12E-05 | 4.13E-07 | 0.1443 | 0.6015 | ||||
| rs7327099 | 5.63E-04 | 1.64E-06 | 4.77E-07 | 0.5073 | 0.5070 | ||||
| rs6042 | 4.42E-04 | 1.76E-05 | 5.89E-07 | 0.9207 | 0.6075 | ||||
| rs11839532 | - | 7.86E-07 | 7.86E-07 | 0.4561 | 0.5065 | ||||
| rs6041 | 1.90E-02 | 9.03E-06 | 9.66E-07 | 0.0146 | 0.5644 | ||||
| MCP-1 | 17 | rs11663180 | 3.37E-05 | 1.03E-03 | 3.88E-07 | 0.5061 | 0.3007 | 18 | ATP9B |
| chr18:76959824 | 3.49E-05 | 1.02E-03 | 3.95E-07 | 0.5075 | 0.2990 | ||||
| rs10468812 | 1.21E-03 | 1.33E-04 | 4.87E-07 | 0.3812 | 0.4848 | ||||
| chr18:76954975 | 2.92E-05 | 1.51E-03 | 5.62E-07 | 0.4298 | 0.2323 | ||||
| rs60585035 | 2.74E-05 | 1.76E-03 | 6.49E-07 | 0.4572 | 0.2203 | ||||
| rs8085999 | 2.70E-04 | 4.51E-04 | 6.79E-07 | 0.3195 | 0.5519 | ||||
| chr18:76891698 | 4.05E-05 | 1.50E-03 | 6.99E-07 | 0.2722 | 0.1835 | ||||
| rs4324200 | 1.45E-04 | 7.18E-04 | 7.23E-07 | 0.1524 | 0.6783 | ||||
| rs59890467 | 3.54E-05 | 1.69E-03 | 7.37E-07 | 0.2713 | 0.1475 | ||||
| rs4471755 | 1.01E-03 | 1.58E-04 | 7.43E-07 | 0.4213 | 0.4191 | ||||
| rs57582689 | 1.49E-04 | 7.35E-04 | 7.54E-07 | 0.1474 | 0.6805 | ||||
| rs4799019 | 2.96E-05 | 1.92E-03 | 7.64E-07 | 0.4017 | 0.2107 | ||||
| rs1942306 | 1.88E-04 | 7.33E-04 | 7.79E-07 | 0.1474 | 0.6806 | ||||
| rs12607019 | 1.46E-04 | 7.33E-04 | 7.79E-07 | 0.1474 | 0.6806 | ||||
| rs1942308 | 1.56E-04 | 7.35E-04 | 7.80E-07 | 0.1475 | 0.6806 | ||||
| rs56894683 | 2.96E-05 | 1.96E-03 | 7.84E-07 | 0.3987 | 0.2088 | ||||
| rs57977665 | 2.97E-05 | 1.96E-03 | 7.87E-07 | 0.3989 | 0.2093 | ||||
| chr18:76891893 | 1.60E-04 | 7.33E-04 | 7.94E-07 | 0.1475 | 0.6806 | ||||
| rs9967354 | 1.61E-04 | 7.33E-04 | 8.00E-07 | 0.1475 | 0.6806 | ||||
| rs9966492 | 2.89E-05 | 2.02E-03 | 8.02E-07 | 0.3736 | 0.1910 | ||||
| chr18:76916979 | 5.83E-05 | 1.39E-03 | 8.21E-07 | 0.3959 | 0.1730 | ||||
| chr18:76895796 | 1.96E-04 | 7.27E-04 | 9.13E-07 | 0.1760 | 0.6762 | ||||
| rs9965326 | 6.55E-05 | 1.50E-03 | 9.70E-07 | 0.3597 | 0.1767 | ||||
| rs35548358 | 7.33E-02 | 1.05E-06 | 5.15E-07 | 0.1802 | 0.4824 | 6 | TREM1 | ||
| rs34689624 | 7.35E-02 | 1.05E-06 | 5.17E-07 | 0.1799 | 0.4830 | ||||
| rs7761652 | 1.58E-01 | 6.05E-07 | 7.92E-07 | 0.1499 | 0.6995 |