Table 2.

Physical properties and cellular functions associated with immunogenity in bacteria, virus and parasites

Enriching features	Bacteria	Viruses	Parasites
Predicted functions	COG U Intracellular trafficking and secretion	Virion membrane	GO function protein binding, catalytic, transporter, transferase activities
	COG M Cell envelope biogenesis, outer memberane	membrane proteins, core proteins	GO function enzymatic, regulator
	COG N Cell motility and secretion		GO function structural molecule and ion channel activity
	COG O Posttranslational modification, protein turnover, chaperones		GO ATP biosynthetic process, proteolysis; metabolic
	COG S		GO transport process
Predicted Computationally	TMHMM=1	TMHMM	TMHMM=1 to 10
	Signal P>=0.7		Signal peptide
	pSortb Outer Membrane		pSort Outer Memberane
	pSortb Periplasmic
	pI 0–5		pI 7–9
Expression	Expression evidence by Mass Spectrometry	abundance of expression	abundance of expression