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Cytochrome c release assay. α/β-peptides D and D*, but not B, elicit cytochrome c release from mitochondria into the cytosol of wild-type but not bax/bak-deficient MEFs. Peptide Bim, which represents the native Bim BH3 domain 26-mer, was included as a positive control. Each peptide was used at 10 μM. P: pellet fraction containing mitochondria, S: soluble fraction containing cytosol. DMSO was used as the solvent for all peptide stock solutions.
