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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Nat Genet. 2015 Oct 26;47(12):1393–1401. doi: 10.1038/ng.3432

Figure 6. Buffering of regulatory variation.

Figure 6

(a) Schematic of chromatin environment at promoter DHSs indicating increased size, accessibility, and density of TF binding relative to distal DHSs. (b) Threshold model of TF occupancy explaining buffering of point changes at strong sites. (c) Frequency of imbalance relative to transcription start sites (TSS) demonstrates buffering within the promoter region. Buffering is strongest between −2.5 kbp and +5.0 kbp of TSS. Bins are labeled by endpoint furthest from TSS. (d) Frequency of imbalance, broken down by site strength as measured by DNase I accessibility across all cell types having a DHS.