Table 4.
Concentrations (ng/mL) and elimination rate (μg/h) of quinine in urine.
| Urinary Quinine Concentrations (ng/mL, ± SEM) | ||||
|---|---|---|---|---|
| Observed Range | Mean | Cmax | Cmin | |
|
| ||||
| Acute Dosing (hrs post first dose) | ||||
| Day 2 (0 -12hrs) | 159 – 13,400 | 2,772 (± 668) | 3,974 (±1215) | 1,569 (±239) |
| Day 3 (24-36 hrs) | 771 – 16,300 | 3,577 (± 563) | 5,880 (±1326) | 2,308 (±308) |
| Day 4 (48-60 hrs) | 860 – 17,300 | 3,830 (±406) | 7,518 (±1445) | 1,898 (±252) |
| Day 5 (72-96 hrs) | 993 – 36,800 | 5,011 (±1045) | 9,863 (±3430) | 1,956 (±257) |
| Washout (hrs post last dose) | ||||
| Day 6 (24-36 hrs) | 309 – 5,130 | 2,061 (± 277) | -- | |
| Day 7 (48-60 hrs) | 126 – 2,820 | 618 (±138) | -- | |
| Day 8 (72 hrs) | 240 – 327 | 296 (±16) | --- | --- |
| Urinary Elimination Rate of Quinine (μg/h, ± SEM) | ||||
| Observed Range | Mean | |||
|
|
||||
| Time post last dose | ||||
| Day 5 (0-12 hrs) | 1034 – 92 | 403 (±30) | ||
| Day 6 (24-36 hrs) | 539 – 40 | 167 (±24) | ||
| Day 7 (48-60 hrs) | 175 – 14 | 53 (±9) | ||
| Day 8 (72 hrs) | 48 – 12 | 31 (±6) | ||
Observed ranges and means are displayed above for quinine urine concentrations (ng/mL) and elimination rate (μg/h). Peak (Cmax) and trough (Cmin) values that occurred during active dosing are also displayed. Calculations were conducted on raw, non-modeled data that was not normalized with respect to creatinine concentrations.