Table 3.

TIL Grade in Primary Melanomas and Association with Survival Outcomes

Number of cases	Survival Associations	Comments	Reference
264	Predicts 8 year OS (brisk 88%, non-brisk 75%, absent 59%)		Clark et al. 1989
548	No survival differences	Compared absent to present TILs only	Barnhill et al. 1996
285	Predicts 5 year OS (brisk 77%, non-brisk 53%, absent 37%)		Clemente et al. 1996
259	Predicts 5 year OS (brisk 100%, non-brisk and absent 71%)	Groups non-brisk and absent TILs in their analysis	Tuthill et al. 2002
887	No survival differences	Groups non-brisk and brisk TILs in their analysis	Taylor et al. 2007
1251	No survival differences		Mandala et al. 2009
515	Predicts 5 year OS (brisk 95%, non-brisk 84%)	Did not address absent TILs	Burton et al. 2011
1865	Predicts 5 year OS	Used their own TIL grading system assigning a score from 0 to 3	Azimi et al. 2012
2845	Predicts 5 year OS (brisk 97%, non-brisk 94%, absent 93%)		Thomas et al. 2012