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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Am J Med Sci. 2015 Dec;350(6):485–497. doi: 10.1097/MAJ.0000000000000530

Table 3.

Diabetes Drugs that Cause Weight Gain and More Weight-Neutral Alternatives

Diabetes Drugs that Cause Weight Gain More Weight-Neutral Alternatives
Insulin

  • More weight gain with short- vs. long-acting

 Biguanides

  • Glucophage, Glumetza, …(metformin)
Sulfonylureas

  • Amaryl (glimepiride)

  • Glucotrol, others (glyburide)

  • Tolinase (tolazamide)

 SGLT2 inhibitors

  • Farxiga (canaflozin)

  • Invokana (dapaflozin)

    Jardiance (empagliflozin)
Thiazolidinediones

  • Actos (pioglitazone)

  • Avandia (rosiglitazone)

 Incretins/GLP-1 agonists

  • Bydureon, Byetta (exenatide)

  • Victoza (liraglutide)
Meglitinides

  • Prandin (repaglinide)

  • Starlix (nateglinide)

 Alpha-glucosidase inhibitor

  • Glyset (miglitol)

  • Precose (acarbose)
DPP4 inhibitors

  • Januvia (sitagliptin)

Abbreviations: SGLT2 = sodium-glucose cotransporter 2, GLP-1 = glucagon-like peptide-1, DPP4 = dipeptidyl peptidase 4